Whether it’s acknowledged or not, “real” nature is all around us, everywhere, in a way that Pluto could never mimic unless of course humans magically terraformed it into existence, or some illusion of it.

It’s odd how easily we forget the simple things, like having a blue sky and a distant horizon. Or feeling the pull of the earth beneath our feet. Or the myriad of subtle scents in our nose, that immerse us even when we are unaware of them.

A little searching online will find you plenty of studies that show how nature, both simple and complex, reduce mental stresses in humans.

It seems prudent to at least assume that the environment in which we arose and for which we are adapted, would be not only better suited for the human body but also for its mind.

As a starting point for research into the effects of a similar, but still far more “natural”, environment: https://en.wikipedia.org/wiki/Winter-over_syndrome

All that said, I suppose it’s possible that humans born on Pluto might fair better. We probably (hopefully) have very few case studies that could even begin to provide some insight into such a scenario. So who knows…