In Infraspace there's no zoning as such (you can do it yourself to some extent with their "districts" feature), it's still early access alpha though with hopefully a lot more to come. For some production you need so many of some of the buildings that it's easier to slap them in their own area.

It does have trains, but they are fairly limited use right now and it's pretty car focused.

I'm trying to just do one super long road in my current game.