I've suspected for a long time that we are missing major stuff from out diet due to changes in both the plants and animals we eat. I look at fruit in the grocery store and it just looks unnatural to me.
https://blogs.scientificamerican.com/observations/vanishing-...
https://www.politico.com/agenda/story/2017/09/13/food-nutrie...
There is some evidence sugar content has increased, from varietal changes, but that's about it.