Disulfiram is a very familiar and very old line drug. It doesn't (directly) stop people from drinking alcohol, but just makes it very unpleasant. Disulfiram interferes with the breakdown of the normal metabolic products of alcohol, which cause nausea, headache, flushing, sweating and other autonomic symptoms. With large amounts of alcohol the interaction can be dangerous, rarely even fatal.

But the article is reporting a different effect altogether. Disulfiram indirectly inhibits glutamate signaling, which produces a putative "antianxiety" effect in an animal model of anxiety. It makes sense in that glutamate is the primary activating neurotransmitter in the brain.

After all existing antianxiety agents like benzodiazepine drugs work by binding to GABA receptors. GABA is the primary inhibitory neurotransmitter. The logic is increase inhibitory effect == reduce activating effect. BTW it's not coincidence that alcohol also binds to GABA receptors, the reason people reach for a drink when they're feeling nervous.

But the problem remains that taking disulfiram for anxiety means using NO alcohol at all. Maybe a few people are OK with this but I bet most will be unwilling to give up having a drink now and again. So it creates a problem since people will forget and with both on board it can be a big headache, in more ways than one.