Specifically to replicant blade runners, I think there is lots of room for soul searching and meaningful play in coming to grips with potentially being a tool/the tool of your own oppression.
Maybe you start as a blade runner but come to champion the replicant cause. Maybe you smuggle the weak and sick off world. Maybe after your day job ticketing replicants for minor infractions you conduct corporate sabotage against the Tyrell Corporation. Maybe you play as a replicant member of an off-world kick-murder squad or captain a replicant gunship off the shoulder of Orion. Maybe you run a chop shop helping replicants bypass retinal scans. The world of Bladerunner is ripe with RP options. In my opinion, it would be a shame to dismiss the opportunity because you can only see problematic themes.
To paraphrase Roy Batty
You saw a slave narrative, I've seen things you people wouldn't believe.
That's a very reductionistic view of material. Blade Runner was always asking a question what makes someone a human.
And how can you be sure you are a human?
https://urbigenous.net/library/how_to_build.html
Philip K. Dick's stories are everything but simple. In link above there is a story was about man undergoing surgery only to discover he has a punch tape inside him. He finds out he's an Android. So he starts messing with the tape, punching out pieces only to discover it materialized a flock of geese. In anger he tears the tape causing entire world to disappear.
Philip K Dick.
To boil it down to slavery is a modern take. His other story Roog about a dog defending his home has a similar premise.
His question is closely related to whether you could figure out you are a copy, whether your could tell actual reality from perceived reality, etc.
This is far from being a settled canon. Ridley Scott claims it is so, but what does he know? Movie makers often create lore that forces fans to go great lengths to explain coherently. Remember that Kessel run in 12 parsecs?!
Whew, glad that playing a murderous grave robber necromancer isn't.
That's why these are called "dystopia" and you're not necessarily playing the good guys, there is nothing "problematic" with it.
I think the new "safe, diverse and inclusive" D&D version is aimed at people concerned by "problematisms". See? there are RPG for everybody.
I feel that, with the right GM, it's a very nice setting to discuss slavery.
And IMO, merely creating such an AI isn't even immoral, as long as we don't force it into labor it wants to escape from.
I guess that is true at some level depending on how one defines "confinement".
It is not clear to me that Roy or Pris are looking to escape their professions rather, they are in love and about to die of "old age". As Roy bluntly states "I want more life".
1: https://remotestorage.blogspot.com/2010/07/douglas-adamss-co...
Remember, the world just acts a backdrop. A horrible person can still try to let their character murder-rape everyone in a Teletubbies RPG. In the end how the story unfolds depends a lot on the party & game master, and what kind of characters/game they want to play.
Gladiators, drafts, totalitarian states, etc.
A lot of them are really just slavery under a nuanced scheme that we’re all fine role playing.
So it's entirely possible that you could start the game as a slave catcher, but if that's not something that you actually want your character to be, then you could definitely try to escape that role! And it would be up to the DM to decide how to respond to your actions...
Edit: Writing this I just thought maybe not since I can’t think of any that focus on running a PoW / Gulag / Concentration camp, whereas this focus on the slave catching.
I'm sure you could make an absolutely offensive game about the topic, but you could also make a game that treats the subject carefully. Do you look askance at Secret Hitler?
Then don't play it?