A simple case in point: the study of logic has been a interesting human endeavor for thousands of years, since at least the time of the Greek and Vedic schools. After thousands of years of study, a major breakthrough was made with the first formalization of propositional logic (as Boolean algebra) by George Boole in 1854. Since then, there has been a search for the simplest foundational formal axioms from which all of propositional logic could be derived. This project ended in 2000 with Wolfram's discovery of, and proof that, [1] is the shortest possible single axiom that can be used as a foundation for all of propositional logic.
[1] ((a⁍b)⁍c)⁍(a⁍((a⁍c)⁍a)=c, where ⁍ is NAND