I'm wondering this too since Windows has built-in antivirus now. https://www.microsoft.com/en-us/windows/comprehensive-securi...
MSE is really all I've used since binning AVG which turned into bloatware.
I feel your pain. We have a load of other crap loaded such as Umbrella that is supposed to protect us from harmful websites. It does stuff like intercept DNS lookups etc. It's such a pile of shite and doesn't work properly when I need VPN into our cloud infrastructure. When it's configured so badly it feels really anti-work. But hey ho, "security reasons".