High refresh rate screens are a reality so you only have 3-6ms to render each frame, as well as high resolution screens at 4k-8k. That's a lot of pixels to push with a CPU on every frame. As another comment points out we also need accessibility. I would generalize this need as "GUIs need to be reinterpretable", this need is not limited to those with disabilities and such a capability can be useful to anyone that wants to customize, automate, and integrate their digital tools.
Are immediate-mode GUIs up to the task? What is driving their authors to pursue this design? Why aren't they choosing a declarative design?