In many ways the familiarity and apparent simplicity of English text is a big challenge, particularly whole pages of text. A great book to read is Just My Type: A Book About Fonts by Simon Garfield. Turns out I live not too far from the resting place of the only matrices of Doves type, at the bottom of the Thames.
My brother talks about setting whole pages by hand, and finding a word missing! Apparently it pays to leave a bit of extra space.