As for the response, it would be unsolicited by the fact the original tweeter did not ask/want a response from the Meme-ster. They tagged the wrong account.
Take this example:
John says to the person he thinks is Brad: I can't believe the weather today!
Emily says to John: What the fuck did you just fucking say about me, you little bitch? I'll have you know I graduated top of my class in the Navy Seals.... etc....
John's reaction to Emily: WTF who the hell is this? Why is she saying these things to me?
Now imagine this happens to be a common mistake that multiple make and Emily responds in this way every time...