There's lots of research on negative metabolic effects of high fructose consumption, particularly on the liver. Here's a couple recent reviews as a starting point for those that are interested:
Mai, Brandon H, and Liang-Jun Yan. “The Negative and Detrimental Effects of High Fructose on the Liver, with Special Reference to Metabolic Disorders.” Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 12 (May 27, 2019): 821–26. https://doi.org/10.2147/DMSO.S198968.
Jensen, Thomas, Manal F. Abdelmalek, Shelby Sullivan, Kristen J. Nadeau, Melanie Green, Carlos Roncal, Takahiko Nakagawa, et al. “Fructose and Sugar: A Major Mediator of Nonalcoholic Fatty Liver Disease.” Journal of Hepatology 68, no. 5 (May 2018): 1063–75. https://doi.org/10.1016/j.jhep.2018.01.019.
And some interesting evolutionary speculation on why effects of fructose might be so powerfully conserved:
Johnson, Richard J., Peter Stenvinkel, Peter Andrews, Laura G. Sánchez-Lozada, Takahiko Nakagawa, Eric Gaucher, Ana Andres-Hernando, et al. “Fructose Metabolism as a Common Evolutionary Pathway of Survival Associated with Climate Change, Food Shortage and Droughts.” Journal of Internal Medicine, October 17, 2019. https://doi.org/10.1111/joim.12993.
BTW, beyond mechanistic research, I think one of the most interesting recent trials was this elegant study done recently in obese children (n=41) where it was shown that over 10 days of isocaloric (calorie-matched) swapping of sugar for starchy carbs resulted in a halving (!) of liver fat, a 68% decrease in DNL (de novo lipogensis = fat produced by the liver), and improved insulin kinetics across the board, showing that fructose was not only uniquely bad from a metabolic perspective even vs glucose, but that the response to removing the fructose was a dramatic and immediate improvement in health markers:
Schwarz, Jean-Marc, Susan M Noworolski, Ayca Erkin-Cakmak, Natalie J Korn, Michael J Wen, Viva W Tai, Grace M Jones, et al. “Effects of Dietary Fructose Restriction on Liver Fat, De Novo Lipogenesis, and Insulin Kinetics in Children with Obesity.” Gastroenterology 153, no. 3 (September 2017): 743–52. https://doi.org/10.1053/j.gastro.2017.05.043.