Isolation hasn't helped in the case of North Korea, so I would not be surprised if it doesn't help in the case of Russia.
I wouldn't support 75 years of isolation in Russia, but a country in free fall might lead to regime change in the not-too-distant-future. I want Putin out. I can see scenarios by which he's out in weeks, months, or a few years.
Even more, I want Lukashenko out before Belarus is a nuclear power. Right now, we could affect regime change without nuclear consequences. That option leaves the table soon.