Russia has plenty of brilliant, highly skilled people. Get as many of them to abandon the nation as possible (and make their journey to a new home as easy as possible). The US, EU and their allies can easily make this happen.
Confronting Russia obviously has to be a many front effort. Oil and gas are valuable resources, yes, and they get a lot of attention in terms of how to best constrain Russia. A well organized brain drain against the Russian economy would also hurt enormously across the next decade.