Don't write code designed to burn CPU with numerical calculations. There is hyper optimisation and then there is the right tool for the job. The speed loss from doing mathS in an interpreter is huge and frankly usually not worth paying.
Python like this is great for low CPU hyper responsive code, or for increasing efficiency of existing constructs.
As a rule of advice to anyone who asks me this, go away and read about the benefits of compiled over interpreted code. There's to much to conver in 30s and frankly if you're worrying about extreme performance you shouldn't be using python... That's not too say I don't think python is awesome, but, write a module in something else :p