Pythran sounds awesome. I've somehow always glossed over it before. That might be due to the name, which made me think it was some Fortran-interop library (and those tend to be old and not what I need)...
If you write quite a bit of numerical code you can often achieve impressive speed ups using pythran with very little changes, it's like numexpr + cython on steroids. I highly recommend checking it out. The community is quite small, so there are still some bugs, Serge the main author is really responsive.