Some stuff looks like it might be implemented well in these OS's, like using DMA, and suchlike. So they could possibly be fast. And yet, I think the way to bet is that they will be slower. Get comfortable with CMSIS, and your results are likely to be substantially faster.
Maybe throw in a bit of FreeRTOS if you feel you need it. I haven't experimented with tinygo yet, but I wonder if that's the way to go if you want concurrency.
I think that the whole notion of abstracting away the machine is an ill-conceived idea anyway, particularly when it comes to microcontrollers. The whole point of mcus is to use their particular features and strengths, which basically the opposite of abstraction.
I dunno, if something is complicated enough to use Zephyr, then maybe it's complicated enough to just ditch it and use a Raspberry Pi.