I have 4 soundcards present on my system (built-in, external webcam, USB audio interface, USB synthesiser) and Pipewire can handle it all at once.
Bluetooth headphones are also handled well. They connect by default with aptX (A2DP mode) but using KDE tray icon, I can easily change it to full-duplex headset mode with mSBC.
And then I can use (not that I would always want to) any of these devices together (e.g. in a DAW).