What I was referring to is that such a situation is highly unlikely. Even if we do not take current labour shortage and the historic lack of IT people into account I am certain that there would be more than enough employers or business partners who do not care about whether or not someone is willing to shake their hand.

But yes, in general if a society places enough value on a social norm to decide whether or not to do business with a certain person it is possible that certain people will be alienated based on their willingness to participate in such a social norm.

And, to address your edit: I am fully aware that we are currently in a pandemic and I am not saying that we should go around and start getting overly close to one another for no reason.

As the original content all the way up this chain I was mostly referring to a time post COVID, assuming that such an outset is realistic. If not then hand shaking will be the least pressing problem regardless.