I second the "Man’s Search for Meaning" recommendation. That book is great for putting one's struggles into perspective, and emphasizing the importance of a "why."
Status, material possessions, wealth, family, prestige - all of it can be taken away from you. But not meaning.
"Siddhartha" or "The Adventures of Huckleberry Finn" might also relate to the meaning of life but they are also not philosophy books. They might be great books but you might be looking for something completely different.