Not sure about how the story with Inkscape looks, but it can be difficult to deliver the reproducible issue. You might have to build it yourself, might have to install a compiler in the right version and so on. Depending on the build story of Inkscape, this can take days of fumbling. Not many users are willing to go through that.
I would say it is OK to open an issue, which is not 100% reproducible, as long as it has not been opened. It allows for the chance, that others can try to find that reproducible way of causing the issue, who are more knowledgable about the software and might have the dev setup already on their machines.