Getting physics and chemistry right is really essential to technological progress. How can technology advance if your physics and chemistry are wrong?
But, what about "softer" sciences, such as psychology or the social sciences? It seems you could be moving in the complete wrong direction with them, and yet still be advancing technologically – because technology largely doesn't depend on them.
And even for the "hard sciences", technology generally only depends on certain areas of them. How much of the Standard Model of physics is actually technologically relevant? Technological progress is strong evidence you've got the technologically-relevant parts of physics right, but is compatible with serious error in low technological-relevance areas. What is the technological relevance of electroweak unification, for example?
We also don't know what we are missing out on. Neuroscience is an area of biological research in which many promises of clinical translation have thus far failed to deliver. Is that because this the brain is very complicated, and we just have to wait longer and invest more before we see more results? Or could it be that we are doing the science wrong, and we'd clinically be in a much better situation now if we were doing it right? How can one tell which of those two possible situations we are actually in?