but, as I pointed out elsewhere, this would not be particularly helpful as it would use an enormous amount of resources to compute something we could probably approximate with a well-trained ML model.

It also wouldn't address questions like biochemistry, enzymatic reactions, and probably wouldn't be able to probe the energetics of interactions accurately enough to do drug discovery.

Now, the question is, does it matter? When do you EVER need to know the exact atomistic, yet alone electronic, trajectory of a single protein starting from a given position within a cell surrounded by waters in a given configuration?

It doesn't really matter. This is the beauty of noise and averages and -- dear to me-- statistical mechanics. At finite temperatures, AKA most everything we experience as living things, quantum details (or precise classical trajectories for that matter) aren't that important for the vast majority of questions we tend to have about a system.