There's still a market for in-person jobs/workers, and people are willing to relocate as they did pre-pandemic. It might be significantly smaller, but if it matters enough on both sides to be in-person, I think it's a factor to consider when growing a team/picking a job.
While I don't have hard numbers, I know a few founders who are seed-stage and need to hire only 2-3 people; they want to be in an office (safely) in their early days. (Who knows what will happen as they grow.) Likewise, many job seekers I talk to want to be in-person and working alongside colleagues (safely) because they miss in-person interactions.
To your last point, I don't know if any angel investors in YC startups take into consideration a startups' willingness/unwillingness to be remote as a signal for whether they should invest. My guess is that there are better signals (technical founder, past experience, progress already made) that are more important deciding factors.