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I use MSG in almost all of my savory cooking at home. Highly underrated flavor enhancer.

OMG thats soo yummy!!! // Followed by a night of headaches and sleeplessness. I understand not everyone gets the side effects though.

does it provide any big opportunities if you've already got something like worchestershiresauce?

yes, it doesn't contain 900 other things like sugar, rotting fish, extra flavorings so you can make things that are much cleaner tasting.