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The Crossover version works well on post-Catalina systems. You can just buy it or... compile their code :) There is a gcenx build available here: https://github.com/Gcenx/homebrew-wine .

IIRC Crossover handles this already, and there's a version of Wine compiled from the Crossover code floating around.

Wine 6 works on M1 macs with 64-bit binaries.

I'm using it for Mikrotik Winbox and it works wonderfully. (Though Mikrotik cares for Wine compatibility).