I'm dreading the day that one of the big AAA publishers acquires Supergiant Games. Hoping that it doesn't happen, but I can't imagine the founders are going to wave off multi-million (or even billion?) dollar offers forever.
I'm sure there will be other indie games, but Supergiant's combination of excellent music, art style, and unique, well polished gameplay is not something you see a lot of.
Maybe it was the HR departments that killed them. Maybe it was, in shifting from art to product, they unlearned the basics of how to make fun. Either way, nothing interesting will come from it for a long time.