The 2008 RoarVM project allowed Squeak to run on a 56 core Tilera chip and was later ported to run on multiprocessor x86 machines:

https://stefan-marr.de/renaissance/

https://github.com/smarr/RoarVM

This was a research project so performance on a single core was poor compared to the official Squeak virtual machine, but it was an interesting exploration of the natural fit between objects/message passing and multiple cores.