I’ve been using Fedora 35 with Wayland and fractional scaling set to 150% on my Framework laptop and it works great for me.
Great stability. Close to the edge of progress. And they focus on delivering real unique value on top of what others have created as opposed to reskinning and hacking Gnome.
I’ve never used Fedora but I’m keen on moving over my personal desktop the next time I have a couple of days to mess around with it.