Although I don't use NoScript (or NotScripts) anymore the web was far less annoying without arbitrary JavaScript. I never had to leave a site because some irrelevant box popped up over the page I was looking at, or about to be.

It will be effective at blocking the Flash-like HTML ads that are going to pop up soon as well. Unless they get really creative with CSS.

I use NoScript, but I have it set up to allow embeds and top-level references. Denying those is a stone's throw away from just turning off javascript completely, which would be tiring.