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Comment by ch0I9daAiO | Hacker News Reader

I wonder how they address the urinary tract issues, especially the bladder. It's one thing when they use it for anesthesia, which is quite rare and sporadic to receive, compared to something like therapy, which might happen more frequently and for longer. Does anyone have any data about that?

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The urinary issues are in people using 100-200x the ketamine you might use even in regular therapy.

https://astralcodexten.substack.com/p/drug-users-use-a-lot-o...

Too bad the world's first "synthetic" to combat this issue, MXE, was made illegal.

It has no bladder problems, and shines light where ketamine is cold.

MXE is the perfect drug. 5g in a few months, stopped cold turkey, felt fine - due to the long lasting and dissipating metabolites that these drugs degrade into.

I am planning on getting some Ketamine soon for my own Christmas present. Too bad I can't have MXE, which is safer, better, and fuckn awesome.

you can even smoke it! (very small amounts. makes you feel like a golden greek god)

If you know where to look on the dark web, MXE can occasionally still be found. The fine folks over at Lizard Labs in NL have also developed DMXE, which is apparently qualitatively nearly identical, though I have yet to be able to acquire any in the US.

I searched for weeks for a domestic Lizard Labs reseller, no luck.

I don't do custom, especially from NL.

Good to know they are still around! May look into their new new new novel lysergamides.

Those were the days my friend. We thought they would never end...

I busted out the 3-MEO-PCP that I had literally buried - at the time, I had thought it was too manic, to schizophrenic.

10 day regime of a small bump for breakfast had be happy for weeks.

do drugs, people

not too much. mostly plants

My understanding is that ketamine therapy doesn't involve many doses of ketamine over a long time, but rather a handful of guided sessions over weeks/months.

The actual implementation of the therapy varies from place to place. In my locale, the treatment does not involve any guides. It's really unfortunate

Urinary tract issues are not that common. They would have to pretty much take higher doses, long-term. It is not a concern as far as this therapy goes.

Last I heard about this in hard reduction groups, people experience this after 1-2 years of chronic daily usage. It's definitely something to keep an eye on. But people would be able to get through many sessions before being at risk.

I'm more worried about people stop being able to afford it, going to black market and and up having a dependency.

Apparently there's a big difference in the quantities of ketamine consumed by recreational users versus people who are prescribed it, 90 grams per month being common for recreation versus 300 mg for treatment.

https://astralcodexten.substack.com/p/drug-users-use-a-lot-o...

I know many heavy and moderate recreational ketamine users and 90g is completely absurd.the really heavy users I know go through a gram per day max. During parties or festivals it can be more. Not to say that there isn't a big difference to therapeutic use.

If I do the math right, that’s like $5k/month or more. I doubt many recreational users consume that much. Not for long anyway.

You tend to get deals on bigger purchases. But it's a pretty typical pattern for people to destroy all their savings, and social capital very quickly during the escalating dose phase of drug addiction. My friend who got hooked liquidated his retirement funds, sold his car, house, borrowed tens of thousands from family & friends & banks, committed insurance fraud, and embezzled from his employer. Probably over $100K and all gone within 18 months to ketamine and meth.

I think it's worth reevaluating the word 'recreational' here. Except for festivals, or longer parties as someone already mentioned 300mg is an enormous amount to consume in one sitting, especially without a good understanding. 90g per month seems quite unsafe.

You could k-hole every night for a month IM'ing 100mg, and that'd still only be 3,000mg. 30 grams of ketamine is an absolutely crazy amount.

Sorry, those numbers are for monthly consumption.

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