Although I guess once it's in orbit, and major problems could be sorted out over the following years with manned repair missions, like they did with hubble
https://en.wikipedia.org/wiki/James_Webb_Space_Telescope#His...
A few hundred million for each launch; heck, the long-term ground support is probably more expensive than the flights and the hardware after a while.
Not anytime soon. The Hubble is in low-earth orbit at an altitude of 540 Km, whereas JWST is at the Earth-Sun L2 point at an altitude range of 370 Mm to 1.5 Gm; further than the Moon. No spacecraft capable of carrying humans beyond LEO has been built since the Apollo missions.
Starship and SLS will change the game, but both are still years away from manned flights.