Hacker News Reader

This paper from Africa Health Research Institute shows a 41x reduction in effectiveness of pfizer vaccine for omicron.

https://www.ahri.org/omicron-incompletely-escapes-immunity-i... https://www.ahri.org/wp-content/uploads/2021/12/MEDRXIV-2021...

View on HN

This preprint also shows reduced antibody neutralization of omicron in comparison to delta (including for double vaccinated + previous infection).

Note the sample sizes for all these studies is small. 12 participants for the AHRI paper and 8 to 20 per group for this one.

https://www.medrxiv.org/content/10.1101/2021.12.07.21267432v...

Sample size doesn't really matter much in this kind of study.

Ideally you'd match it to some population of interest. For my own medical affairs, I don't care what grand-pappy's results are here, I want to know how cousin Tim fairs.

Why not? I’m no statistician, so my basic understanding is you should always prefer bigger sample sizes to ensure statistically significant findings.

This paper doesn't even attempt to measure effectiveness. It measures neutralization titers which is a totally different thing.

Reply on news.ycombinator.com