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My naive understanding of why it's so difficult to stop coronaviruses in general from spreading is due to the virus moving between humans and animals. If that's true, and if that causes virus mutation, then is it possible to stop the mutations even with a theoretical 100% global vaccination?

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It may have been possible to contain it early on. Way too late now. It's here to stay forever, with new strains constantly evolving.

I would say the goal of vaccinations is to minimize death and to prevent medical systems from being overwhelmed.

I don't think COVID-19 is a disease that can be eradicated.

The fewer hosts out there though, the fewer opportunities it has to mutate.

Since every household that has a pet has additional hosts, there is no way to meaningfully reduce the number of hosts.

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