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I'm not particularly paranoid, but I do notice mineral buildup over time from tap water. In fact, my dishwasher may be end-of-life because of it.

(and of course, as others have said, bacteria, amoeba, disinfecting chemicals, minerals from the house's pipes... did I mention that I'm not paranoid? :) :) )

But YMMV -- if you're happy with reverse osmosis, go for it.

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Do you ever run a descaling cycle? You can use citric acid or a cleaning pack that's basically just Citric acid.

Plumber told me to put vinegar into it, which sounds like the same principle.

I have a dishwasher that says an upright glass of vinegar is an option if dishwasher cleaning tablets aren't powerful enough but warns that it is harsh on the plastics and seals.

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