The Kwikset smart key v3 can't be picked because you get no feedback until all pins are set. You can decode them one pin at a time with expensive specialized tools such as a micro camera put into the cylinder but they will keep someone out for a while so they do their job. You still need to cut a custom key to get in even when you decode it so it is time consuming.
A Medeco will keep out even an experienced lockpicker for a while since pins must be in the right rotation and the right heights.
Beyond that there are really good Disk Detainer locks like the Protec 2 that have no feedback until all discs are correct. There are 0 public confirmed defeats of them.
Beyond that you get into hybrid digital keys like the Cliq. Then you can combine an cylinder known to not have any defeats with a second set of pins that can only be engaged after an AES challenge/response between a microcontroller in the key and one in the lock.
These also have never been defeated.
There are also solutions like the Bowley lock that don't expose the tumblers to the outside world and can only be defeated with many hours of work making custom tools for that specific lock.
I could go on and on.
The reason you can't buy good locks at US hardware stores is fully because the uneducated masses rejected high security locks once companies like master lock pumped out $5 locks with 10/10 security ratings in spite of any informed child being able to open them.
I would love to see people like LPL put their lawyer hats on and sue these companies for dangerously deceptive advertising.