locate is, for whatever reason, tragically slow. The database format it uses is nonsensical and completely optimized for size on very outdated assumptions.
I use an implementation I have written in the shell itself whose database format is nothing more than every file path on the system separated by null bytes, that is simply grepped to find files; the speed difference is absurd.
—— — time locate */meme.png
/storage/home/user/pictures/macro/meme.png
real 0m0.885s
user 0m0.806s
sys 0m0.010s
—— — time greplocate /meme.png$
/storage/home/user/pictures/macro/meme.png
real 0m0.089s
user 0m0.079s
sys 0m0.011s
This implementation is highly naïve and simplistic, and offloads all the searching to GNU Grep, yet outperforms the actual `locate` command by an order of magnitude.