I tried a Moonlander and really didn't jive with it, then tried a KinesiS Freestyle and love it.
Upon reflection, it's the ortholinear layout that made the Moonlander so much less comfortable for me.
To solve the problem you describe I use a non-slip material by a company called Dycem[0], which I understand is primarily used by amputees and people with limited use of their limbs.
I've always gotten that niggly 'slight misalignment' feeling, ever since my first Ergodox 7-8 years ago. I know exactly what you're talking about and Dycem almost completely eliminates this for me. I lay my wrist rests and my board on it, and can make intentional microadjustments as I type, but those stay in place for weeks as long as I don't accidentally knock them out of place.
It's not cheap and there may be other similar alternatives, but I can say this one works.
Also because I type with the keyboard on my lap and I had to use the split on a piece of plywood to keep it flat...
I have it on a "gaming" mouse mat, i.e. an enormous mouse mat.