With what substance, and how often/how much?
The schedule is 5 on, 2 off, and it's taken in conjunction with B3 (Niacin) and Lion's Mane (a non-psychoactive mushroom). All together, the mix promotes neurogenesis.
Combined with tools like meditation, exercise, and a supportive environment, it can do wonders to help re-construct toxic patterns built from long-term depressions and anxieties.