MS has had "software protection" systems, probably three different schemes by now, that check for this. It's more to prevent malware but also means it's incredibly difficult to patch out MS-approved malware without running afoul of the system integrity checks.

On of the appeals of the LTSC branch is that it doesn't have a lot of user-hostile feature kits in it to begin with, so you're not constantly fighting to keep them turned off.

People will come with ways to bypass it for sure, but Microsoft is hoping to make it as hard as possible, so that the average user doesn't bother to switch. And unless the government intervenes, it will work.

You can do that. But programs like EdgeDeflector can’t be distributed doing changes like that. Every antivirus vendor including Microsoft SmartScreen will rightly block it for doing destructive changes.