But is it solely the chemical changes in the brain that "fix" the depression, or does it also have to do with integrating what you've seen and experienced into your worldview?
https://youtu.be/Xu1FMCxoEFc?t=5928
99:33 But one of the things that came up
99:35 and is a fundamental question that I had,
99:37 that I think probably many of you are asking,
99:38 is does the experience that one has on these compounds
99:43 make a difference for whether or not somebody gains relief
99:46 from depression, from these psilocybin journeys or not?
99:50 In other words, does it matter what they talk about?
99:52 Does it matter what they think about?
99:53 Does it matter if they have a good trip or a bad trip?
99:56 And I don't want to hold you in too much suspense,
99:58 I'll let Matthew provide the more thorough answer.
100:00 But what's really interesting
100:02 is there are some common themes to psilocybin administration
100:08 and experience that lead to relief from depressive symptoms,
100:11 but they are subjectively very varied,
100:17 meaning that whether or not people feel
100:20 they had a good experience or a bad experience,
100:22 whether or not people thought about their parents
100:24 or thought about the color of the ceiling,
100:27 doesn't seem to have too much of an impact
100:30 on whether or not they receive relief
100:32 during these studies in these clinical studies.
100:37 It seems like different people can have
100:38 lots of different experiences and still receive benefit.
100:42 And that points to something deeper.
100:45 It points to the fact that these drugs,
100:48 which is really what they are,
100:49 are rewiring neural circuitry in a common way
100:53 despite a diversity of experience while on the drug.
100:57 And that itself is really interesting.
100:58 And it takes us back to a place that we've been before
101:01 in this discussion, which is layer five of the cortex.
101:04 This area that ketamine seems to impact as well
101:06 by generating rhythms of the,
101:08 I mentioned one to three Hertz activity
101:10 in layer five of certain areas of the cortex.