I finally got them to work well in wayland (literally last night with sway) which supports different resolutions/scaling per monitor unlike xorg. Try out wayland on your desktop, that may be the last part you need. wdisplays to size things.

This also seems to be an issue with (albeit likely main use) of running your monitor at double DPI, like you would with a laptop and side monitor. With a 43" 4k monitor and some old 2560x1440 27" monitors the default worked great.

Now I just gotta figure out how to get my 2nd nvidia card working on my desktop to get that 5th monitor turned on.

Yeah this is several hours of fiddling. I had this working years ago but things got broken, they seem to be on the way to getting fixed.

And as other articles have said, I've spent as much or more time unf**ing python on windows, installing WSL2, etc.

Really the only things holding me back from a full time windows box were pubg (not a reason now), fusion 360 (can use a VM), and 5+ monitors. If I get those monitors running it's go time. Luckily I have the same computer config at home and at work so it may happen.

What's the issue? The only issue I have is not having a good way to get a consistent font/UI sizes across (switching between) different monitors/machines. But I have/had that problem with macOS too.

Not for me on Ubuntu 20.04. I use fractional scaling on my laptop and it works perfectly. Just prefer deb installers instead of flatpak and snap, because flatpak and snap aren’t ready yet. HiDPI works great.