I had 3 shots of Avastin to fix a neovascularization in my retina [1] around the end of 2010.

I have to say, it's not a very pleasant treatment. I vividly remember the image of the needle inside my eyeball and the liquid squeezing in (Avastin has a refractive index slightly different than the vitreos). But at least now I have a cool icebreaker when I get my flu shot every now and then :D

[1] - https://pubmed.ncbi.nlm.nih.gov/17011951/