African sleeping sickness is an infection that results in a person going into a kind of coma. The parasite constantly changes its molecular interface with the host which is supposed to confuse the hosts immune system. This places a huge burden on the immune system and results in the host becoming hungry all the time, despite already being full. These patients will stuff themselves while growing progressively more tired. And eventually they fall asleep permanently. Inflammatory signals slow metabolism or something to that effect and this change in metabolism causes the body to feel as though it’s starved of energy and so the patients feel hunger. Inflammation and metabolism are linked.
A man with schizophrenia was cured after a bone marrow transplant. The New York Times wrote about it recently. Symptoms of age including cognitive decline have been reversed in mice and humans through blood dilution/ blood transfusion probably due to reduction in the concentration of inflammatory molecules in the blood that are produced by ones own body. Inflammation/metabolism is the biggest medical revolution on the horizon. Especially since COVID has made it a grant-worthy topic now and doctors can’t deny that chronic fatigue syndrome is real anymore. It’s funny how all those people who insisted that CFS wasn’t real are now nowhere to be found to answer for their mistake.