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if detonated
The article is a brilliant piece of writing, but scattered through it, you can gather the bits and pieces of math that would describe why it's not strategically practical.
- Bomb weight / size scales roughly linearly with bomb yield. How are you going to get that massive bomb over to France? The aircraft required to haul it over would be exceptionally vulnerable. If you want to use a rocket, you'd need something on the order of the Apollo Saturn-V rocket to lob it over (especially for 1960's technology), and that rocket would as well would be vulnerable on the launch pad. Good luck hiding it while you fuel it up. Defending nuclear weapons (cough silos / subs cough) was/is no small task.
- The troposphere (which accounts for the main density of the atmosphere) is only about 13 miles in height, on average. It's thinner near the poles and thicker near the equator. But anyhow, past a certain yield, you literally really do blow a hole in the atmosphere. At that point, the atmosphere acts like a tamper, channelling much of the additional yield into outer space.
To which end, Sakharov was right. The big bombs were massive publicity stunts, and to the degree that the Soviet leadership pursued them, they were wasting money on propaganda projects.