Over a decade later, my wrists hardly ever bother me. Physical therapy taught me to regularly stretch my wrists, and how to strengthen them. I began pursuing other activities which further strengthened my wrists (rock climbing is particularly great, so long as you avoid overdoing it and injuring yourself worse).
My basic advice to people now is:
1) Follow the Pomodoro technique, or whatever it takes to force yourself to get up, stretch, and move around for at least five minutes per hour. We all sort of hear that and nod, but think about how many times you've gotten really deep into a problem and sat there, twisted like a pretzel as you try to solve it, for hours on end. You have to condition yourself to take real, meaningful breaks.
2) Sit up straight, dammit. In every photo we ever see of new startups, how many people are sitting with good posture? None of them.
3) Get a keyboard with light-touch Cherry key switches. I'm partial to the Kinesis ergo line, but there are others.
4) Get active. Straighten your spine and go for a walk around the block a few times per day. Take up yoga, climbing, martial arts, or weight lifting. Focus on improving posture, flexibility, and balanced strength. Find some hobby that will get you away from the computer.