It depends on the suburb. Midwestern suburbs don't really have the downtown in the same way large cities do. IME they are either just glorified strip malls or touristy places. (TBH I'd really like to know how so many chain restaurants can remain in business... is it just a real estate investment?).
Once you account for some states have terrible weather, dysfunctional state governments, higher property taxes, etc. it might not make sense to trade a a net 20% change in overall CoL if it means you have significantly less to do. If your first thoughts are kids, pets, and gardening than sure the midwest is pretty good. If your primary concerns are career advancement, educated social/dating pool, variety in food and music, niche/luxury hobbies like skiing or surfing, etc. then your options for places to live becomes essentially drastically smaller and more competitive.
That said there are certain midwest cities that might strike a good balance.