Why is the answer to "the Ultimate Question of Life, the Universe, and Everything" the number 42? An interesting Christian twist might be ...

    * GIVEN ...

    * the number of (hu)mankind, 3x for emphasis in some contexts where
      humans want to stand completely alone, is "666"

    * the atom for human is "6"

    * the number most often associated with divinity in the bible is "7"

    * THEN ...

    * the product of interaction of the divine with humanity is 7 * 6 = 42
      (of course this firmly puts humanity at the apex of earthly, and perhaps
      universal, entities, and many would object)

EDIT: clarification on first GIVEN