Part 1 is mostly about the body of the plane - https://youtu.be/lapFQl6RezA
& part 2 is mostly about the powertrain - https://youtu.be/Sf6H8kSunRA
They discuss the dramatic increase in the need for titanium parts around 18 minutes into the first video. https://youtu.be/lapFQl6RezA?t=1090
When aluminum and carbon are in direct contact, galvanic corrosion is an issue. The only way they could make a plane with carbon fiber wings, fuselage, and empennage, was to replace most metallic elements with titanium. The final 787 is 15% titanium by weight.
Titanium is tough to work with, and I can see how problems would arise when you redesign what must be thousands of parts.