I have a little RSI but I have taken steps so that it doesn't bother me anymore (switching to Dvorak layout was probably the best move).
Actually, my health problems are with my skin. When I'm sitting at a computer, my skin seems to get itchy - maybe there isn't enough blood circulating or my posture is too stressful.
A couple other people mentioned standing desks. I tried a make-shift one for a couple days but didn't really like it. I might give it another try though.