Anecdata: a close friend has suffered from terrible migraines for years. Triptans such as Sumatriptan/zolmatriptan helped, if taken with anti-sickness meds, but they were needing to take them too often and getting dependency headaches from them.

Over the years they tried many things which didn't really help, or seemed to help but then didn't, or were inconclusivbe.

About a year ago they started on Ajovy (fremanezumab), a CGRP inhibitor. Its been like magic. A simple injection every month (you can do it yourself - they courier them over and you keep them in the fridge) and barely any migraines. Sometimes one or two towards the end of the month when the next jab is due. And no real side effects as far as can be told.

Its unusual to come accross a medicine that works so well for something as intractable as migraines.

UK specific: Originally they were paying for the Ajovy after getting prescribed it by the brilliant National Migraine Center (https://www.nationalmigrainecentre.org.uk/) - its expensive. But after it was shown to work managed to get it on the NHS via a referral to a specialist.